Fri Jan 03 2025

53 articles - From Friday Dec 27 2024 to Friday Jan 03 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Aliment Pharmacol Ther

Management of Patients With Refractory Reflux-Like Symptoms Despite Proton Pump Inhibitor Therapy: Evidence-Based Consensus Statements.

The management of rRLS should be personalised, based on shared decision-making regarding the role of diagnostic testing to confirm or rule out GERD as a basis for treatment optimisation. Anti-reflux procedures should not be performed without objective confirmation of GERD.

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Am J Gastroenterol

ACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis.

Monitoring with clinical, endoscopic, and histologic assessments is recommended to assess for treatment response and follow patients over time with maintenance therapy. When evaluating and following patients with EoE, consideration should be given to assessing and controlling both the inflammatory and fibrostenotic aspects of disease.

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Meta-analysis

meta-analyses and systematic reviews

Am J Gastroenterol

Predictors of Outcomes After Gastric Peroral Endoscopic Myotomy for Refractory Gastroparesis: A Systematic Review.

Currently, there are limited reproducible predictors of response to GPOEM among patients with refractory gastroparesis. Robust prospective studies investigating scalable, reproducible, and actionable biomarkers of treatment response are required.

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Gastrointest Endosc

Cold versus hot snare endoscopic mucosal resection of colorectal polyps: meta-analysis of randomized controlled trials.

Cold EMR is associated with lower risk of delayed bleeding and perforation but higher risk of recurrent/residual neoplasia compared to hot EMR.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Aliment Pharmacol Ther

Analysis of Antroduodenal Motility in Patients With Hypermobility Spectrum Disorders/Hypermobile Ehlers-Danlos Syndrome.

The prevalence of antroduodenal dysmotility was not different between both groups, but enteric dysmotility was less common in the HSD/hEDS group (13% vs 34%, p = 0.006). Delayed gastric emptying rates were similar, suggesting that delayed gastric emptying is more relevant for patients with HSD/hEDS and gastrointestinal symptoms.

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Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival.

On dabigatran, 47% of 119 patients achieved portal vein recanalization over 32 months of follow-up which was higher than the spontaneous RR (21.4%) in an untreated cohort. High Factor VIII Ag was a predictor of non-recanalization. Dabigatran was safe in cirrhosis (CP-A and B) while further work is needed in CP-C.

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Impact of Nucleos(t)ide Analogs on Major Clinical Outcomes in Patients With Chronic Hepatitis B: A 10-Year French Nationwide Cohort Study.

Tenofovir was associated with a higher risk of HCC compared with entecavir, although no difference in the composite outcome of mortality or liver-related events was observed between the two treatments.

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Lubiprostone Reduces Fat Content on MRI-PDFF in Patients With MASLD: A 48-Week Randomised Controlled Trial.

Lubiprostone was well tolerated and reduced liver fat content as measured by MRI-PDFF in patients with MASLD over 48 weeks. Lubiprostone appears promising to treat MASLD and warrants more extensive studies to confirm such efficacy.

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Am J Gastroenterol

Global, regional, and national burden of primary liver cancer attributable to metabolic risks: an analysis of the Global Burden of Disease Study 1990-2021.

Primary liver cancer attributable to high BMI and/or high FPG imposes an increasingly substantial clinical burden on global public health, particularly in high SDI countries. Rapid growth trends are also found in middle-SDI countries.

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Ileal Predominance in Crohn's Disease Is Associated With Increased Intestinal Surgery and Biological Therapy Use, With Lower Treatment Persistence.

CD location with ileal predominance is associated with a distinct therapeutic pattern, including higher biologic use, lower treatment persistence, and increased rates of intestinal resections.

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Novel Concepts on the Functional Neuroanatomy of the Anorectum: Implications for Anorectal Neuropathy and Neuromodulation Therapy.

This illustrated review provides a new understanding of the afferent and efferent pathways between the rectum, spinal cord, and brain, and a framework for clinical implications of anorectal neuropathy, such as anal sphincter or rectal sensory or rectal accommodation dysfunction, causing bowel problems. Insights into the functional neuroanatomy provide an improved mechanistic understanding of anorectal symptoms and could facilitate the development of neurophysiological tests such as translumbosacral anorectal magnetic stimulation and neuromodulation treatments such as sacral neuromodulation and translumbosacral neuromodulation treatment.

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Optimal population screening strategies for liver fibrosis associated with metabolic dysfunction-associated steatotic liver disease.

The proposed population risk stratification approach using the SAFE score is simpler and substantially more effective, yielding more subjects with liver fibrosis while requiring less resources compared to the currently recommended algorithm.

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Clin Gastroenterol Hepatol

Modified Crohn's Disease Exclusion Diet Maintains Remission in Pediatric Crohn's Disease; Randomized Controlled Trial.

The study was underpowered to show whether CDED was superior to EEN in sustaining remission. However, two weeks of EEN followed by CDED was effective in inducing remission in CD, with most CDED patients maintaining remission up to 24 weeks. Despite dietary restrictions for 24 weeks, the BMI Z-score improved significantly in the CDED group but not in the EEN group (NCT02843100).

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Gastroenterology

Human enteric glia diversity in health and disease: new avenues for the treatment of Hirschsprung disease.

Two major enteric glial classes were identified in the pediatric intestine, highlighting the significant postnatal contribution of Schwann-like enteric glia to glial heterogeneity. Crucially, these glial subtypes persist in aganglionic segments of HSCR patients, offering a new target for their treatment using 5-HT agonists.

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In Obesity, Esophagogastric Junction Fat Impairs Esophageal Barrier Function and Dilates Intercellular Spaces via HIF-2α.

We have elucidated molecular mechanisms whereby visceral fat of obese patients can impair esophageal barrier integrity by secreting substances that generate ROS, which activate HIF-2α in esophageal epithelial cells. These mechanisms could render the esophagus of obese individuals vulnerable to damage by acid and other noxious agents.

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Gastrointest Endosc

Superiority of Linear-Array EUS over MRCP in Diagnosing Pancreas Divisum: Evidence from a Multicenter Retrospective Study in Oriental Cohorts.

Our study conclusively demonstrates that L-EUS significantly outperforms MRCP in diagnosing pancreas divisum. L-EUS exhibits markedly higher sensitivity, and area under the curve (AUC) values. However, its diagnostic reliability decreases in the presence of pancreatic duct stones or severe pancreatitis.

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Gut

Aspirin is associated with lower risk of pancreatic cancer and cancer-related mortality in patients with diabetes mellitus.

Aspirin use may be an oncopreventive strategy to reduce PC risk in patients with T2DM. Further studies are warranted to validate the study findings.

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Mutational signatures define immune and Wnt-associated subtypes of ampullary carcinoma.

Immunogenicity and Wnt pathway associations, emphasised by the mutational signatures, defined patients with prospective sensitivity to either immunotherapy or Wnt pathway inhibitors. This emphasises a novel mutational signature-based AMPAC classification with prognostic potential, suggesting prospective implications for subgroup-specific management of patients with AMPAC.

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Trends and cross-country inequality in the incidence of GI cancers among the working-age population from 1990 to 2021: a Global Burden of Disease 2021 analysis.

While the ASIR of GI cancer is trending downwards among the WAP, high incidence rates, regional variability and an unequal burden of disease emphasise the need for flexible, targeted medical interventions to support policymaking and medical resource allocation.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Aliment Pharmacol Ther

Editorial: Evaluating the Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes and Hyperferritinemia.

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Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B.

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Editorial: Where to Start in Ulcerative Colitis?

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The Proteomics of MASLD Progression: Insights From Functional Analysis to Drive the Development of New Therapeutic Solutions.

The application of cutting-edge methodologies to investigate the blood proteome in MASH is yielding insights that facilitate the elucidation of disease mechanisms and the identification of optimal noninvasive biomarkers. However, several challenges remain to be addressed in future research, including the generalisation of results on a global scale, the optimisation of analytical technologies and the implementation of large longitudinal studies to gain insights into the molecular mechanisms that underpin the development of advanced disease.

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Clin Gastroenterol Hepatol

Differential Efficacy of Advanced Therapies in Inducing Remission in Ulcerative Colitis Based on Prior Exposure to TNF Antagonists.

There is significant heterogeneity of treatment efficacy with different advanced therapies in inducing remission in patients with UC based on prior exposure to TNF antagonists, with plausible potentiation of JAK inhibitors and attenuation of lymphocyte trafficking inhibitors. Future studies on the mechanistic basis for these observations are warranted.

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Gastroenterology

Catching up with creeping fat - unravelling the mysteries of the mesentery in Crohn's disease.

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J Hepatol

Targeting Tumour Endothelial Cells in Liver Cancer: The end of beginning.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Am J Gastroenterol

Antiperistaltic Effect of Cold Water on Upper Gastrointestinal Motility During Endoscopic Ultrasound.

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Aspirin Use and the Risk of Colorectal Cancer.

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Colitis Cystica Profunda: A Rare Cause of Rectal Bleeding.

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Correlation Between Cholecystectomy and the Risk of Gastric Cancer.

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Response to Liao and Lai.

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Response to Sun and Wu.

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Response to Zhou et al.

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Understanding the Highs and Lows of Gastrointestinal Inflammation.

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Visible Peristalsis in a Patient Referred for Chronic Intestinal Pseudo-Obstruction.

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Visual Endoscopic Retrograde Appendicitis Therapy vs Antibiotic Therapy for Treatment of Uncomplicated Acute Appendicitis.

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Clin Gastroenterol Hepatol

Bouveret Syndrome Treated with Endoscopic Lithotripsy and Gallbladder Access via Cholecysto-Duodenal Fistula.

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Gut

Accuracy of histopathology evaluation in diminutive colonic polyps diagnosed as neoplastic by computer-aided characterisation.

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Hepatology

Author Index.

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Category Index.

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The Liver Meeting: San Diego, California, Nov 15-19, 2024.

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Letters&Replies

Letters to the editors and authors’ replies

Aliment Pharmacol Ther

Editorial: Evaluating the Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients With Type 2 Diabetes and Hyperferritinaemia-Authors' Reply.

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Editorial: Ultralow HBsAg Levels and the Prediction of Cure in Chronic Hepatitis B-Authors' Reply.

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Letter: Meta-Analysis: Prevalence of Frailty and Associated Adverse Events in Inflammatory Bowel Disease-Authors' Reply.

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Letter: Meta-Analysis: Prevalence of Frailty and Associated Adverse Events in Inflammatory Bowel Disease.

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Gastroenterology

Analysis of "Prevotella Is Associated With Sex-Based Differences in Irritable Bowel Syndrome".

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Gut

Colonic motility investigation by modern techniques: time to 'reclaim' the value of physiology?

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Frequency of de novo <i>PRSS1</i> pathogenic variants in a French cohort of idiopathic pancreatitis.

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SPHINX, a Guardian of Wisdom.

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J Hepatol

Optimal Timing To Initiate Antiviral Prophylaxis of MTCT: More Required to Be Done.

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Response to: Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research.

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Roux-en-Y gastric bypass in a patient with Wilson's disease and obesity.

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Therapeutic Plasma Exchange in Acute Liver Failure: can the data be trusted?

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